CYP Inhibition Screen Assay Using LC-MS/MS

The drug probe substrates used by Profacgen include finacin, bupropion, diclofenac, mefentoin, dextromethorphan, midazolam, tolbutamide, and warfarin recommended by the FDA.We use LC-MS / MS to detect changes in the concentration of the probe substrate and its specific metabolites, determine the peak area of the corresponding metabolites, and combine the in vitro-in vivo and pharmacodynamic-pharmacokinetic models, determine the effect of drugs on CYPs inhibition, calculate the corresponding IC50, evaluate compound-mediated inhibition, and evaluate potential drug-drug interactions.

https://www.profacgen.com/services/cyp-inhibition-screen-assay-using-lc-ms-ms